Hi - last year I attempted the CTR. Because I am a scientist, I pitched the idea to my lab (http://www.tracd.chhs.colostate.edu) to do a study on me during the race. I don't think there are many people that would like to have their race complicated by what we did, but I was willing and able because of my own curiosity. Also, since the rules say no help during the race, it took someone that knew what the scientific objectives were and how the methods worked to have the proper control during the study. The study we did was related to the interests of our lab in that we study muscle and mitochondria remodeling. We do this mostly related to aging and disease, but in this case we were wondering if the muscle could remodel to keep up with the demands of the race. We did a muscle biopsy before and after the race, and then another set of biopsies before and after a period of equal length in which I was doing normal training as a control period. Here is a link to a blog that is for general consumption:https://ispyphysiology.com/2017/10/12/muscle-rebuilding-on-the-colorado-trail/
In that blog is a link to the published paper (http://jap.physiology.org/content/early/2017/09/07/japplphysiol.00457.2017). The paper is still in its pre-print form because it has been accepted and is available online but has not gone to print yet. Anyway, I encourage you to read the blog if you'd like, but more importantly the paper if you are scientifically inclined. It is an actual science, rather than an opinion (albeit an n of 1), on one aspect of the demands of the race.
Enjoy